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Evaluación del Riesgo de Malignidad de los Nódulos Pulmonares Solitarios


Tumor-Associated Autoantibodies: Re-Optimization of EarlyCDT—Lung Diagnostic Performance and its Application to Indeterminate Pulmonary Nodules. Healey GF, Macdonald IK, Reynolds C, et al. J Cancer Ther. 2017; 8:506–517.


Autoantibody Signature Enhances the Positive Predictive Power of Computed Tomography and Nodule-Based Risk Models for Detection of Lung Cancer. Massion PP, Healey GF, Peek LJ, et al. J Thorac Oncol. 2017; 12(3):578–584.


Cost-effectiveness of an autoantibody test (EarlyCDT—Lung) as an aid to early diagnosis of lung cancer in patients with incidentally detected pulmonary nodules. Edelsberg J, Weycker D, Atwood M, et al. PLoS ONE. 2018; 13(5): e0197826.

Estratificación de los pacientes de riesgo para la detección.

Detection in Blood of Autoantibodies to Tumour Antigens as a Case-Finding Method in Lung Cancer Using the EarlyCDT—Lung Test (ECLS): Study Protocol for a Randomized Controlled Trial. Sullivan FM, Farmer E, Mair FS, et al. BMC Cancer. 2017; 17:187. 


Progress with an RCT of the Detection of Autoantibodies to Tumour Antigens in Lung Cancer Using the EarlyCDT—Lung Test in Scotland (ECLS). Sullivan F & Schembri S. J Thorac Oncol. 2015; 10(Suppl 2):S306.


Audit of the Autoantibody Test, EarlyCDT—Lung, in 1600 Patients: An Evaluation of its Performance in Routine Clinical Practice. Jett JR, Peek LJ, Fredericks L, et al. Lung Cancer. 2014; 83:51–55.

Validación Técnica y Clínica

Signal Stratification of Autoantibody Levels in Serum Samples and Its Application to the Early Detection of Lung Cancer. Healey GF, Lam S, Boyle P, et al. J Thorac Dis. 2013; 5(5):618–625.

EarlyCDT—Lung Test: Improved Clinical Utility Through Additional Autoantibody Assays. Chapman CJ, Healey G, Murray A, et al. Tumor Biology. 2012; 33(5):1319–1326.


EarlyCDT—Lung: an Immuno-biomarker Test as an Aid to Early Detection of Lung Cancer. Lam S, Boyle P, Healey G, et al. Cancer Prev Res. 2011; 4(7):1126–34.


Immuno-biomarkers in Small Cell Lung Cancer: Potential Early Clinical Signals. Chapman CJ, Thorpe AJ, Murray A, et al. Clin Cancer Res. 2011; 17(6):1474–1480.


Clinical Validation of an Autoantibody Test for Lung Cancer. Boyle P, Chapman CJ, Holdenrieder S, et al. Ann Oncol. 2011; 22(2):383–9.


Technical Validation of an Autoantibody Test for Lung Cancer. Murray A, Chapman CJ, Healey G, et al. Ann Oncol. 2010; 21(8):1687–93.